2-[(Trimethylsilyl)ethynyl]-3-pyridinamine(CAS: 947330-64-5)

2-[(Trimethylsilyl)ethynyl]-3-pyridinamine (CAS: 947330-64-5) is a crystalline solid with a molecular weight of approximately 263.4 g/mol. It has a low solubility in water but is more soluble in organic solvents like dichloromethane and acetonitrile. The compound exhibits limited reactivity, primarily through the silyl ethynylation moiety, which can undergo substitution reactions under certain conditions.

2-[(Trimethylsilyl)ethynyl]-3-pyridinamine (CAS: 947330-64-5) can be synthesized through a multi-step process starting from pyridine and silyl ethynyl chloride. The key steps include alkyne coupling reactions and amination, often catalyzed by a palladium complex. The overall yield is around 70-80%, with good selectivity for the desired amine product.

2-[(Trimethylsilyl)ethynyl]-3-pyridinamine (CAS: 947330-64-5) is primarily used in pharmaceuticals for the synthesis of intermediate compounds. It also has applications in the development of novel materials, such as polymers and sensors, due to its unique chemical properties.

When handling 2-[(Trimethylsilyl)ethynyl]-3-pyridinamine (CAS: 947330-64-5), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. Store the compound in a well-ventilated area and avoid inhalation of dust or vapors. In case of a spill, use appropriate absorbent materials and follow the safety data sheet (SDS) for disposal instructions. Always work in a fume hood to minimize exposure and follow all standard laboratory safety procedures.