Ethyl 1H-pyrrole-3-carboxylate(CAS: 37964-17-3)

Ethyl 1H-pyrrole-3-carboxylate (CAS: 37964-17-3) is a colorless or white crystalline solid. It has a molecular weight of approximately 140.16 g/mol and a solubility in water of less than 1 g/L. This compound is moderately reactive, especially towards nucleophiles and bases. It is soluble in common organic solvents such as methanol, ethanol, and acetone.

Ethyl 1H-pyrrole-3-carboxylate (CAS: 37964-17-3) can be synthesized via the condensation of 3-bromopropionic acid ethyl ester and pyrrole. The reaction typically uses a catalytic amount of a base such as potassium carbonate, and is performed in an inert solvent like dimethylformamide (DMF) or N,N-dimethylacetamide (DMAc). The yield is generally around 70-80%, and the method is both economical and efficient.

Ethyl 1H-pyrrole-3-carboxylate (CAS: 37964-17-3) is used in the pharmaceutical industry for the synthesis of certain drug candidates. It also finds application in the production of organic semiconductors and as a precursor in the development of new materials for sensors and polymers. Its versatile chemical properties make it valuable in these industries.

When handling Ethyl 1H-pyrrole-3-carboxylate (CAS: 37964-17-3), it is essential to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up with caution, using appropriate absorbents. Always refer to the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) for detailed handling and disposal instructions.