2-Ethoxy-4,6-difluoropyrimidine(CAS: 166524-65-8)

2-Ethoxy-4,6-difluoropyrimidine is a white crystalline solid with a molecular weight of approximately 223.14 g/mol. It is slightly soluble in water and has good solubility in organic solvents like DMSO and acetonitrile. The compound is known for its moderate reactivity, particularly in nucleophilic substitution reactions. It is stable under normal storage conditions but should be protected from moisture and light.

2-Ethoxy-4,6-difluoropyrimidine can be synthesized via nucleophilic substitution reactions using 4,6-difluoropyrimidine and ethoxy magnesium bromide as the starting materials. The reaction is typically performed in anhydrous tetrahydrofuran (THF) under an inert atmosphere. The yield is usually good, around 70-80%, and the product can be purified by recrystallization from a suitable solvent.

2-Ethoxy-4,6-difluoropyrimidine is primarily used in the pharmaceutical industry for the synthesis of various medicinal compounds, particularly in the development of antiviral and anticancer drugs. It also finds applications in polymer science and as a reagent in analytical chemistry for sensor development.

When handling 2-Ethoxy-4,6-difluoropyrimidine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, lab coat, and safety goggles. Work should be conducted in a well-ventilated fume hood. Spills should be cleaned up carefully using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.