Compound Q&A
How is 2-Ethoxy-4,6-difluoropyrimidine (CAS: 166524-65-8) typically synthesized?
Answer
2-Ethoxy-4,6-difluoropyrimidine can be synthesized via nucleophilic substitution reactions using 4,6-difluoropyrimidine and ethoxy magnesium bromide as the starting materials. The reaction is typically performed in anhydrous tetrahydrofuran (THF) under an inert atmosphere. The yield is usually good, around 70-80%, and the product can be purified by recrystallization from a suitable solvent.
About
CAS No
166524-65-8
English Name
2-Ethoxy-4,6-difluoropyrimidine
Molecular Formula
C6H6F2N2O
Molecular Weight
160.12 g/mol
SMILES
CCOC1=NC(=CC(=N1)F)F
InChIKey
SGVUAJWRAOSPNC-UHFFFAOYSA-N
Last Updated: 2025-12-25 13:43
