3-Bromo-5-(trifluoromethyl)-1H-pyrazole(CAS: 93608-11-8)

3-Bromo-5-(trifluoromethyl)-1H-pyrazole (CAS: 93608-11-8) is a crystalline solid with a molecular weight of 243.01 g/mol. It is poorly soluble in water but soluble in organic solvents like dichloromethane and acetonitrile. It exhibits moderate reactivity, particularly under basic conditions, and is prone to nucleophilic substitution reactions.

3-Bromo-5-(trifluoromethyl)-1H-pyrazole can be synthesized via a Swern oxidation of 5-(trifluoromethyl)-1H-pyrazole followed by bromination. The reaction typically involves the use of oxalyl chloride and dimethyl sulfoxide as the reagents, and the yield can reach up to 85%.

3-Bromo-5-(trifluoromethyl)-1H-pyrazole is used in the pharmaceutical and chemical industry for the preparation of intermediates. It is also employed in the development of new materials for sensors and semiconductors due to its unique electronic and structural properties.

When handling 3-Bromo-5-(trifluoromethyl)-1H-pyrazole (CAS: 93608-11-8), it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be managed using appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.