L-2,6-Difluorophenylalanine(CAS: 33787-05-2)

L-2,6-Difluorophenylalanine is a crystalline solid with a molecular weight of approximately 218.09 g/mol. It is slightly soluble in water and more soluble in organic solvents. Chemically, it exhibits reactivity typical of amino acids and can undergo peptide bond formation under appropriate conditions. Its stability is moderate, with potential for hydrolysis under basic conditions.

L-2,6-Difluorophenylalanine is typically synthesized via kinetic resolution of (S)-2,6-difluorophenylalanine using chiral auxiliaries or enzymatic methods. The process involves careful control of reaction conditions to achieve high enantiomeric excess and good yield. Common catalysts include chiral auxiliaries or specific enzymes.

L-2,6-Difluorophenylalanine finds applications in the pharmaceutical industry for the synthesis of chiral pharmaceuticals. It is also used in polymer chemistry for the development of certain biodegradable polymers. Additionally, it has potential in the sensor and semiconductor industries for specific applications requiring chiral molecules.

When handling L-2,6-Difluorophenylalanine, use appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Handle in a well-ventilated area or fume hood to avoid inhalation. Store in a cool, dry place away from direct sunlight. In case of spill, handle carefully and follow standard laboratory procedures for disposing of organic chemicals. Always refer to the Safety Data Sheet (SDS) for detailed safety information.