ent S-(+)-Atomoxetine Hydrochloride(CAS: 82857-39-4)

ent S-(+)-Atomoxetine Hydrochloride is a crystalline compound with a molecular weight of approximately 278.86 g/mol. It is freely soluble in water and has a solubility of 55 mg/mL at 25°C. The compound exhibits low reactivity under normal conditions but can be sensitive to strong acids and bases. It is stable in air and light but should be stored in a closed container to prevent degradation.

ent S-(+)-Atomoxetine Hydrochloride is synthesized via a multistep process involving the use of chiral auxiliary, asymmetric synthesis, and hydrochloric acid. The key steps involve the formation of a chiral intermediate, followed by an enantioselective reduction and hydrochloride formation. The process yields a high enantiomeric excess and good overall yield, typically around 70-80%.

ent S-(+)-Atomoxetine Hydrochloride is primarily used in the pharmaceutical industry as an active pharmaceutical ingredient for treating attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also used in research for studying the effects of selective norepinephrine reuptake inhibitors. While it has potential applications in other fields, its main use is in the development and production of medications.

When handling ent S-(+)-Atomoxetine Hydrochloride, it is crucial to use personal protective equipment (PPE), including gloves, safety glasses, and a lab coat. It should be stored in a cool, dry place away from direct sunlight and heat sources. In case of a spill, it should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.