(S)-Alpha-allyl-proline hydrochloride(CAS: 129704-91-2)

(S)-Alpha-allyl-proline hydrochloride is a crystalline solid with a molecular weight of approximately 221.24 g/mol. It has a pKa of about 1.8 and is soluble in water and organic solvents. The compound is reactive towards nucleophiles and exhibits good stability under acidic conditions but can undergo hydrolysis in the presence of bases.

(S)-Alpha-allyl-proline hydrochloride is usually synthesized via a Wittig reaction between allyl bromide and proline. The reaction is catalyzed by a Lewis acid such as aluminum trichloride, and the product is obtained with good yield and high selectivity. The reaction typically proceeds in an organic solvent such as dichloromethane.

(S)-Alpha-allyl-proline hydrochloride is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the chemical industry for the production of chiral intermediates. The compound can be found in some polymer synthesis processes and may have applications in sensor technology due to its reactivity.

Proper laboratory safety measures should be observed when handling (S)-Alpha-allyl-proline hydrochloride. Wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhalation of the compound. Spills should be cleaned up immediately using an appropriate solvent and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed information on handling and storage.