Aclarubicin(CAS: 57576-44-0)

Aclarubicin is a semi-synthetic antitumor agent with a molecular weight of approximately 432.31 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and dimethyl sulfoxide. Aclarubicin exhibits significant antitumor activity and has a reactive phosphate group that makes it susceptible to nucleophilic attack, leading to DNA damage and cell death.

Aclarubicin is synthesized by modifying daunorubicin through acylation. The synthesis involves a series of steps including alkylation, acylation, and cyclization, with the use of catalysts like sulfuric acid. The process typically achieves high yields and selectivity, making it a common method for producing this compound in pharmaceutical applications.

Aclarubicin is primarily used in the pharmaceutical industry for its antitumor properties. It is also of interest in research for developing new anticancer drugs. Although not extensively used in industries such as polymers, sensors, or semiconductors, its unique chemical properties make it relevant in specialized research and development contexts.

When handling Aclarubicin, it is crucial to wear appropriate personal protective equipment (PPE) including gloves, lab coat, and safety goggles. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up promptly using appropriate absorbents, and the area should be decontaminated. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency response procedures.