Diethyl (4-formylphenyl)phosphonate(CAS: 72436-45-4)

Diethyl (4-formylphenyl)phosphonate is a colorless or pale yellow liquid with a molecular weight of approximately 241.24 g/mol. It is slightly soluble in water but highly soluble in organic solvents. The compound is known for its reactivity, particularly towards nucleophiles and bases, making it useful in various chemical reactions. It crystallizes in the orthorhombic system at room temperature.

Diethyl (4-formylphenyl)phosphonate is typically synthesized by the reaction of diethyl phosphite with 4-formylphenol in the presence of a base such as sodium hydroxide. The reaction yields the target compound with high selectivity and good yield. Catalysts like pyridine are sometimes used to enhance selectivity and reaction rate.

Diethyl (4-formylphenyl)phosphonate is used in the pharmaceutical industry for the synthesis of certain drugs, in polymer chemistry for modifying properties of organic materials, in sensor technology for detection applications, and in semiconductor manufacturing for etching processes. Its versatility in organic synthesis makes it valuable across multiple sectors.

When handling Diethyl (4-formylphenyl)phosphonate, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be carefully managed using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.