6-Chloro-1,3-benzoxazole(CAS: 227197-72-0)

6-Chloro-1,3-benzoxazole (CAS: 227197-72-0) is a crystalline solid with a molecular weight of approximately 173.01 g/mol. It has a solubility of about 2.1 g/100 mL in water and is poorly soluble in common organic solvents. The compound is generally stable under normal conditions but can undergo slow hydrolysis in the presence of moisture. It is moderately reactive and can participate in nucleophilic substitution reactions.

6-Chloro-1,3-benzoxazole can be synthesized by the condensation of 4-chlorobenzaldehyde and urea. This reaction can be carried out in the presence of a suitable catalyst, such as p-toluenesulfonic acid. The yield and selectivity can be optimized by controlling the reaction conditions, such as temperature and solvent choice.

6-Chloro-1,3-benzoxazole finds applications in various industries. It is used as a precursor in the synthesis of pharmaceuticals, particularly in the production of antifungal and antibacterial agents. It also has applications in the development of sensors, semiconductors, and as a building block in the polymer industry.

When handling 6-Chloro-1,3-benzoxazole (CAS: 227197-72-0), it is important to use appropriate personal protective equipment (PPE), including safety goggles, gloves, and a lab coat. This compound should be handled in a fume hood due to its potential for generating harmful vapors. In the event of a spill, it should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. For comprehensive safety information, always consult the Safety Data Sheet (SDS).