(2-Fluoro-3-quinolinyl)boronic acid(CAS: 745784-10-5)

(2-Fluoro-3-quinolinyl)boronic acid is a crystalline solid with a molecular weight of approximately 268.11 g/mol. It is slightly soluble in water and ethanol. It shows moderate reactivity with typical boronic acid behavior in organometallic reactions. Its specific gravity is around 1.2 g/cm³, and it has a melting point of about 120°C. This compound is often used in organic synthesis and medicinal chemistry.

(2-Fluoro-3-quinolinyl)boronic acid can be synthesized via a classical Suzuki coupling reaction using 2-fluoroquinoline and boronic pinacol ester. The reaction is catalyzed by palladium(II) acetate in the presence of a base like triphenylphosphine. The yield is generally around 70-80%, with high regioselectivity for the boronation at the 3-position of the quinoline ring.

(2-Fluoro-3-quinolinyl)boronic acid finds applications in the pharmaceutical industry for drug synthesis, particularly in the development of new drugs targeting specific biological pathways. It is also utilized in the polymer industry for modifying properties of polymers and in semiconductor manufacturing for developing advanced materials.

When handling (2-Fluoro-3-quinolinyl)boronic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store the compound in a cool, dry place away from sources of heat and moisture. In case of a spill, use a fume hood and appropriate absorbent materials for cleanup. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.