1-(2-Fluorophenyl)-3-(4-nitrophenyl)-1H-pyrazole-4-carbaldehyde(CAS: 618101-78-3)

1-(2-Fluorophenyl)-3-(4-nitrophenyl)-1H-pyrazole-4-carbaldehyde is a crystalline compound with a molecular weight of approximately 340.08 g/mol. It has low solubility in water but is more soluble in organic solvents such as ethanol and acetonitrile. The compound exhibits typical reactivity for aldehydes, including nucleophilic addition reactions and condensation reactions.

1-(2-Fluorophenyl)-3-(4-nitrophenyl)-1H-pyrazole-4-carbaldehyde can be synthesized by the reaction of 2-fluorophenyl hydrazine with 4-nitrobenzaldehyde. The synthesis typically involves condensation reactions under acidic conditions, with yields ranging from 70-85%. Suitable catalysts include acetic acid and other Lewis acids.

1-(2-Fluorophenyl)-3-(4-nitrophenyl)-1H-pyrazole-4-carbaldehyde finds applications in the pharmaceutical industry for the synthesis of various drug intermediates. It is also used in the sensor technology and semiconductor industries due to its unique chemical properties and potential for electronic applications.

When handling 1-(2-Fluorophenyl)-3-(4-nitrophenyl)-1H-pyrazole-4-carbaldehyde, proper personal protective equipment (PPE) should be worn, including gloves, safety glasses, and a lab coat. Fume hoods should be used during handling to minimize inhalation risks. Spills should be handled carefully using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed spill and emergency procedures. Storage should be in a cool, dry place away from direct sunlight and other reactive materials.