Captopril | CAS No. 62571-86-2

Captopril

Basic Information

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CAS Number

62571-86-2

Molecular Formula

C9H15NO3S

Molecular Weight

217.29 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

104-108 °C

Boiling Point

427.043°C at 760 mmHg

Density

1.2447 (rough estimate)

Flash Point

212.1±27.3 °C

Solubility

H2O: 0.1 g/mL, very slightly hazy, colorless

Refractive Index

-127.5 ° (C=1.7, EtOH)

Specific Rotation

-129.5 º (c=1, EtOH)

SMILES

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CC(CS)C(=O)N1CCCC1C(=O)O

InChI

InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

InChIKey

FAKRSMQSSFJEIM-RQJHMYQMSA-N

LogP

0.6279000000000001

pKa

3.7, 9.8(at 25℃)

Topological Polar Surface Area

57.61 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

244

Safety Information

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Hazard Statement

H317 May cause an allergic skin reaction
Sensitization, Skin

H361 Suspected of damaging fertility or the unborn child
Reproductive toxicity

Stability

Stable. Incompatible with strong oxidizing agents.

Sensitiveness

Sensitive to air

Toxicity

LD50 in mice (mg/kg): 1040 i.v.; 6000 orally (Keim)

Synonyms & References

English

SA333
CAPTOPRIL [WHO-DD]
SQ 14,225
Lopac0_000302
CAPTOPRILUM [WHO-IP LATIN]
HMS3259G10
captopril
1-[(2s)-3-mercapto-2-methylpropionyl]-l-proline
HB3636
1-(D-3-Mercapto-2-methyl-1-oxopropyl)-L-proline (S,S)
SQ-14225
Tensoprel
SBI-0050290.P004
D00251
(2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline
NCGC00023654-04
s2051
HMS3260N06
Captopryl
Spectrum5_001587
C06867
(S)-1-((S)-3-mercapto-2-methylpropanoyl)pyrrolidine-2-carboxylicacid
SQ -14225
Lopirin [Switzerland]
KBio2_003736
Acediur
HMS2095C19
SA-333
BRD-K54529596-001-15-6
SR-01000000039-2
CAPTOPRIL [HSDB]

MDL Number

MFCD00168073

FAQ

What is Captopril (CAS: 62571-86-2)?

Captopril is an angiotensin-converting enzyme (ACE) inhibitor used primarily in the treatment of hypertension. Its chemical formula is C9H17NO3S, and it is a white to pale yellow crystalline powder with a molecular weight of 217.3 g/mol. It is soluble in water and has a bitter taste. Captopril is known for its effectiveness in lowering blood pressure and reducing the risk of heart failure.

What are the main uses of Captopril (CAS: 62571-86-2)?

Captopril is mainly used in pharmaceuticals as a medication for hypertension and heart failure. It is also employed in research for studying cardiovascular diseases and in industrial applications for the synthesis of other compounds. Due to its ACE-inhibiting properties, it plays a key role in managing conditions related to high blood pressure and is a common drug in clinical settings.

Is Captopril (CAS: 62571-86-2) safe?

Captopril is generally considered safe when used as directed, but it may cause side effects such as cough, dizziness, or kidney issues. It is important to follow safety guidelines and consult a healthcare professional before use. Proper handling and storage are essential to maintain its efficacy and ensure safety during administration.

How should Captopril (CAS: 62571-86-2) be stored?

Captopril should be stored in a cool, dry place away from light. It is typically kept in a sealed container at a temperature between 15°C and 30°C. Maintaining proper humidity levels is crucial to prevent degradation. Always store it in a secure location to avoid exposure to moisture or direct sunlight, ensuring its stability and quality over time.