Imidazo[1,2-a]pyridin-8-ol(CAS: 69214-22-8)

Imidazo[1,2-a]pyridin-8-ol is a crystalline solid with a molecular weight of approximately 195.21 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol. The compound is known for its reactivity in aromatic substitution reactions and its stability under normal conditions.

Imidazo[1,2-a]pyridin-8-ol can be synthesized via the condensation of 2-methylpyridine and cyanamide, followed by hydrogenation to reduce the nitrile group. Commonly used catalysts include palladium on carbon, and the yield can be up to 85% with good selectivity.

Imidazo[1,2-a]pyridin-8-ol is primarily used in the pharmaceutical industry for the development of potential antitumor agents. It also finds applications in the synthesis of functional materials for sensors and semiconductors.

When handling Imidazo[1,2-a]pyridin-8-ol, it is important to use appropriate personal protective equipment (PPE) such as gloves and goggles. Work in a fume hood to avoid inhalation. Spills should be handled carefully, and the material safety data sheet (MSDS) should be referred to for specific disposal instructions.