1-(5-Bromo-2-fluoro-3-pyridinyl)ethanone(CAS: 1111637-74-1)

1-(5-Bromo-2-fluoro-3-pyridinyl)ethanone is a crystalline solid with a molecular weight of approximately 266.04 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. This compound is known for its reactivity, particularly in nucleophilic substitution reactions and electrophilic aromatic substitution reactions.

1-(5-Bromo-2-fluoro-3-pyridinyl)ethanone is typically synthesized via aromatic substitution reactions, where bromo or fluoro groups are introduced into the pyridine ring. Common methods include electrophilic aromatic substitution using bromine or fluorine in the presence of Lewis acids like aluminum chloride. The yield is generally good, and the method is selective.

1-(5-Bromo-2-fluoro-3-pyridinyl)ethanone is used in the pharmaceutical industry for the synthesis of intermediates in drug development. It is also utilized in the sensor industry for the preparation of functionalized materials and in the semiconductor industry for certain photoresists and etchants.

Safety precautions include the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Handling should be done in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific guidance.