1-Boc-4-(4-aminobutyl)piperazine(CAS: 745048-07-1)

1-Boc-4-(4-aminobutyl)piperazine is a white crystalline solid with a molecular weight of approximately 264.4 g/mol. It has good solubility in common organic solvents such as DMF and DMSO. The compound is relatively stable under normal conditions but can undergo hydrolysis in basic conditions. Its pKa is around 20, indicating strong basicity.

1-Boc-4-(4-aminobutyl)piperazine is commonly synthesized via the coupling of 4-aminobutylpiperazine with tert-butyloxycarbonyl chloride in the presence of a base like triethylamine. The reaction typically involves the formation of a Boc-protected secondary amine. The process yields a high percentage of the desired product, with good purity that can be achieved through column chromatography.

1-Boc-4-(4-aminobutyl)piperazine finds application in pharmaceuticals, particularly in the development of new drugs and as a prodrug for various therapeutic uses. It is also used in polymer chemistry for synthesizing functional polymers and in sensor technology for its ability to bind to specific molecules.

When handling 1-Boc-4-(4-aminobutyl)piperazine, it is important to wear appropriate personal protective equipment (PPE) including gloves and goggles. The compound should be stored in a cool, dry place away from heat sources and direct sunlight. In case of spill, it should be cleaned up using appropriate absorbent material and disposed of according to local hazardous waste regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.