3-iodo-1H-indazol-4-amine(CAS: 885521-28-8)

3-Iodo-1H-indazol-4-amine (CAS: 885521-28-8) is a crystalline solid with a molecular weight of approximately 246.01 g/mol. It has low water solubility, making it less soluble in water compared to ethanol. The compound is known for its reactivity towards nucleophiles and can participate in various chemical reactions such as substitution and condensation reactions.

3-Iodo-1H-indazol-4-amine is typically synthesized through a multistep process involving the condensation of indazole-4-carboxylic acid with iodomethane followed by reduction to form the amine. Other methods may involve the direct substitution of a nitrogen atom in an indazole derivative with iodine using a suitable catalyst and selective conditions to achieve high yield.

3-Iodo-1H-indazol-4-amine (CAS: 885521-28-8) is primarily used in pharmaceutical research for its potential as an intermediate in drug synthesis. It is also explored for its applications in the development of sensors and potentially in the semiconductor industry due to its electronic properties.

When handling 3-iodo-1H-indazol-4-amine (CAS: 885521-28-8), it is important to use appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate safety procedures, and the material safety data sheet (MSDS) should be consulted for detailed handling and disposal information.