Baricitinib Impurity 21(CAS: 335654-06-3)

Baricitinib Impurity 21 is a crystalline solid with a molecular weight of approximately 347.33 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and dimethyl sulfoxide. It is rather stable under normal conditions but can react with strong oxidizing agents.

Baricitinib Impurity 21 is synthesized through a series of organic reactions, including alkylation and cyclization. The process involves the use of a palladium catalyst for cross-coupling reactions and careful temperature control to achieve high yield and selectivity.

Baricitinib Impurity 21 is primarily used in the pharmaceutical industry for quality control and impurity profiling of baricitinib, a JAK inhibitor used in the treatment of autoimmune diseases. It is also of interest in academic and research settings for studying the effects of impurities in drug development.

When handling Baricitinib Impurity 21, it should be done in a well-ventilated area or a fume hood. Wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Handle in a spill-proof container to prevent contamination and dispose of waste according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed safety information.