8-Bromo[1,2,4]triazolo[1,5-a]pyridine(CAS: 868362-18-9)

8-Bromo[1,2,4]triazolo[1,5-a]pyridine is a crystalline compound with a molecular weight of approximately 232.13 g/mol. It has a low solubility in water but is more soluble in organic solvents like dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). The compound is relatively stable under normal conditions but can react with strong bases. It typically exists as a solid at room temperature.

8-Bromo[1,2,4]triazolo[1,5-a]pyridine is commonly synthesized via the reaction of bromine with 1,2,4-triazolo[1,5-a]pyridine in the presence of a Lewis acid catalyst, such as aluminum chloride (AlCl3). The synthesis typically yields a mixture of products, with high selectivity and good overall yield under optimized reaction conditions.

8-Bromo[1,2,4]triazolo[1,5-a]pyridine is primarily used in the pharmaceutical and chemical industries. It serves as a precursor in the synthesis of various bioactive molecules and can be utilized in the development of novel drugs. Additionally, it may find applications in the synthesis of materials for sensors and semiconductors.

When handling 8-Bromo[1,2,4]triazolo[1,5-a]pyridine, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the safety data sheet (SDS) for specific handling and disposal instructions.