(2S)-3-Methyl-2-phenylbutanoic acid(CAS: 13490-69-2)

(2S)-3-Methyl-2-phenylbutanoic acid is a white crystalline solid with a molecular weight of approximately 188.24 g/mol. It has a melting point of about 78-80°C and is slightly soluble in water. This compound is reactive and can undergo esterification and amide formation. It is also susceptible to hydrolysis under acidic or basic conditions.

(2S)-3-Methyl-2-phenylbutanoic acid can be synthesized via several routes, including the Knoevenagel condensation of ethyl acetoacetate with phenylacetonitrile, followed by hydrolysis. Another method involves the Claisen condensation of 2-methyl-2-phenylpropanoyl chloride with phenylacetonitrile. These methods yield the compound in good to excellent yields with moderate selectivity.

(2S)-3-Methyl-2-phenylbutanoic acid finds applications in the pharmaceutical industry for the synthesis of certain drugs, in the polymer industry for modifying properties of polymers, and in the sensor industry for developing chemical sensors. It is also used in the semiconductor industry as a chemical intermediate.

When handling (2S)-3-Methyl-2-phenylbutanoic acid, use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood due to its volatility and potential reactivity. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.