(2S)-2-amino-3-(1-benzyl-1H-imidazol-4-yl)propanoic acid(CAS: 16832-24-9)

The (2S)-2-amino-3-(1-benzyl-1H-imidazol-4-yl)propanoic acid (CAS: 16832-24-9) is a crystalline solid with a molecular weight of approximately 292.33 g/mol. It has a pKₐ value of around 9.5 and is moderately soluble in water. This compound reacts readily with bases due to its amino group and displays moderate reactivity in the presence of acids. It is stable under normal storage conditions but should be protected from moisture and air exposure.

The synthesis of (2S)-2-amino-3-(1-benzyl-1H-imidazol-4-yl)propanoic acid (CAS: 16832-24-9) is typically achieved via a multistep process. Starting from 1-benzyl-1H-imidazole and glycine, the reaction proceeds through condensation followed by amidation. This process involves the use of coupling agents like HATU or EDC and a suitable base like DIPEA. The yield is usually around 70-80%, and the product can be purified by column chromatography or recrystallization.

The (2S)-2-amino-3-(1-benzyl-1H-imidazol-4-yl)propanoic acid (CAS: 16832-24-9) is used in the pharmaceutical industry as an intermediate for the synthesis of various drug candidates. It is also utilized in the sensor industry for its ability to interact with metal ions and in semiconductors for its electronic properties. Its unique chemical structure makes it valuable in polymer synthesis for developing functional materials and in biochemistry for studying protein interactions.

When handling (2S)-2-amino-3-(1-benzyl-1H-imidazol-4-yl)propanoic acid (CAS: 16832-24-9), it is important to use proper personal protective equipment (PPE) including gloves and eye protection. Store the compound in a cool, dry place away from moisture and air. In case of a spill, contain it using absorbent materials and dispose of it according to local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.