(1R,2R)-2-iodocyclopropanecarboxylic acid(CAS: 692288-05-4)

(1R,2R)-2-Iodo-cyclopropanecarboxylic acid is a crystalline solid with a molecular weight of approximately 228.01 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. The compound is moderately reactive due to the presence of the iodo group, which can participate in substitution reactions. It is also prone to hydrolysis under basic conditions.

(1R,2R)-2-Iodo-cyclopropanecarboxylic acid can be synthesized via the iodination of cyclopropanecarboxylic acid using NIS and pyridine as a catalyst. The reaction provides good selectivity and yield, with the iodo group being introduced at the correct stereochemistry. Post-synthesis purification is typically achieved through recrystallization from ethanol.

(1R,2R)-2-Iodo-cyclopropanecarboxylic acid is primarily used in the pharmaceutical and chemical synthesis industries. It serves as a key intermediate in the synthesis of various bioactive compounds and pharmaceuticals. Additionally, it has potential applications in polymer chemistry and as a sensing agent in analytical chemistry.

When handling (1R,2R)-2-iodocyclopropanecarboxylic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to reduce exposure to the compound. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.