tert-Butyl 2-oxo-7-azabicyclo[2.2.1]heptane-7-carboxylate(CAS: 152533-47-6)

tert-Butyl 2-oxo-7-azabicyclo[2.2.1]heptane-7-carboxylate is a white crystalline solid with a molecular weight of approximately 212.28 g/mol. It has a high solubility in organic solvents like dichloromethane and ethyl acetate but is poorly soluble in water. This compound is moderately reactive, showing some tendency towards hydrolysis and base-catalyzed reactions. It is typically used in organic synthesis due to its stability and reactivity.

tert-Butyl 2-oxo-7-azabicyclo[2.2.1]heptane-7-carboxylate can be synthesized via a multi-step process, starting from 3,7-dimethyl-2,6-octadiene-1,5-dione. The reaction involves the epoxidation of the diene followed by an intramolecular Diels-Alder reaction, followed by protection and deprotection steps. This compound is commonly synthesized using catalytic amounts of acid or base, with high yields and good regioselectivity.

tert-Butyl 2-oxo-7-azabicyclo[2.2.1]heptane-7-carboxylate is primarily used in pharmaceutical research, polymer synthesis, and sensor applications. Its unique structure makes it an important intermediate in the synthesis of complex molecules. It is also utilized in the preparation of polymers and as a reagent in organic chemistry due to its stability and reactivity.

tert-Butyl 2-oxo-7-azabicyclo[2.2.1]heptane-7-carboxylate should be handled in a well-ventilated area and ideally in a fume hood to minimize exposure to potential fumes. Protective equipment such as gloves, safety goggles, and a lab coat should be worn. This compound is not particularly hazardous but care should be taken to avoid contact with skin and eyes. In case of spill, the area should be cleaned up using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for specific spill response procedures.