[2-(Benzyloxy)-4-fluorophenyl]boronic acid(CAS: 848779-87-3)

[2-(Benzyloxy)-4-fluorophenyl]boronic acid (CAS: 848779-87-3) is a white crystalline solid with a molecular weight of approximately 295.22 g/mol. It has low solubility in water (0.01 g/100 mL at 25°C) but is more soluble in organic solvents such as dichloromethane and methanol. Chemically, it is a boronic acid derivative and is known for its reactivity in nucleophilic aromatic substitution reactions and its ability to form stable complexes with transition metals.

[2-(Benzyloxy)-4-fluorophenyl]boronic acid (CAS: 848779-87-3) is commonly synthesized through a multistep process involving the formation of a benzylic ether followed by the introduction of a fluoro group and the subsequent conversion to boronic acid. This typically involves the use of reagents such as benzyl alcohol, fluoroacetic acid, and boron reagents like sodium or potassium borohydride. The reaction conditions usually require temperature control and the use of appropriate solvents to ensure high yield and selectivity.

[2-(Benzyloxy)-4-fluorophenyl]boronic acid (CAS: 848779-87-3) is primarily used in the pharmaceutical industry for the synthesis of drug precursors and intermediates, as well as in the polymer industry for the development of advanced materials. It also finds applications in the field of sensors for its unique chemical reactivity and in semiconductor manufacturing due to its stability and reactivity.

When handling [2-(Benzyloxy)-4-fluorophenyl]boronic acid (CAS: 848779-87-3), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure to dust and vapors. Spills should be handled with caution, using appropriate absorbents and disposing of waste according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.