4-Desmethoxy-4-chloro Omeprazole(CAS: 863029-89-4)

4-Desmethoxy-4-chloro Omeprazole is a white to off-white crystalline solid with a molecular weight of approximately 406.63 g/mol. It is slightly soluble in water and ethanol. Chemically, it is highly reactive due to the presence of the chlorine substituent and the sulfonamide group, which can participate in various chemical reactions.

4-Desmethoxy-4-chloro Omeprazole is synthesized through a multi-step process involving the methylation of omeprazole, followed by the introduction of a chlorine atom at the 4-position. The synthesis involves the use of catalysts and requires high selectivity to achieve high yields, typically around 80-90%.

4-Desmethoxy-4-chloro Omeprazole is primarily used in the pharmaceutical industry for the treatment of gastric and duodenal ulcers. It is a key intermediate in the synthesis of omeprazole and other proton pump inhibitors, which are widely used in clinical settings.

When handling 4-Desmethoxy-4-chloro Omeprazole, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work must be conducted in a well-ventilated area or a fume hood to prevent inhalation of the compound. In case of spillage, immediately clean up the area using appropriate procedures and ensure proper disposal. Always refer to the safety data sheet (SDS) for detailed guidelines.