2-Bromo-4,6-difluoroaniline(CAS: 444-14-4)

2-Bromo-4,6-difluoroaniline is a crystalline solid with a molecular weight of 235.01 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. It is chemically reactive, particularly towards nucleophiles and reducing agents.

2-Bromo-4,6-difluoroaniline is typically synthesized via the reaction of 4,6-difluoroaniline with bromine in the presence of a suitable Lewis acid catalyst. The reaction yields a high selectivity towards the brominated product, with a yield ranging from 70% to 90%.

2-Bromo-4,6-difluoroaniline is primarily used in the pharmaceutical and polymer industries. It serves as a precursor in the synthesis of various pharmaceutical compounds and is also utilized in the formulation of certain polymer additives and sensors.

When handling 2-Bromo-4,6-difluoroaniline, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. In case of a spill, neutralize with sodium bicarbonate and dispose of according to local regulations. Consult the Safety Data Sheet (SDS) for detailed guidelines.