1-(6-Fluoro-3-pyridinyl)ethanone(CAS: 84331-14-6)

1-(6-Fluoro-3-pyridinyl)ethanone (CAS: 84331-14-6) is a crystalline solid with a molecular weight of approximately 182.13 g/mol. It is slightly soluble in water but has good solubility in organic solvents such as ethanol and acetone. Chemically, it is relatively stable under normal conditions but can undergo nucleophilic substitution reactions. It has a melting point around 116-118°C.

1-(6-Fluoro-3-pyridinyl)ethanone (CAS: 84331-14-6) can be synthesized via a one-pot reaction starting from 3-pyridyl ethanone and fluoroform in the presence of a base such as sodium hydroxide. The reaction yields a high purity product with good selectivity and yield, making it a suitable method for industrial production.

1-(6-Fluoro-3-pyridinyl)ethanone (CAS: 84331-14-6) is primarily used in the pharmaceutical industry for the synthesis of various APIs and intermediates. It also finds applications in the production of sensors and semiconductors due to its unique electronic properties.

When handling 1-(6-Fluoro-3-pyridinyl)ethanone (CAS: 84331-14-6), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The compound should be handled in a well-ventilated area or fume hood to avoid inhalation. In case of a spill, it should be cleaned up carefully using absorbent materials and the area should be flushed with water. Always refer to the SDS (Safety Data Sheet) for detailed safety information.