Ethyl 1H-pyrazolo[3,4-B]pyridine-5-carboxylate(CAS: 1256824-48-2)

Ethyl 1H-pyrazolo[3,4-B]pyridine-5-carboxylate (CAS: 1256824-48-2) is a crystalline compound with a molecular weight of approximately 244.23 g/mol. It has a high solubility in organic solvents such as ethanol and methanol. Chemically, it is relatively stable but can react with strong bases. Its reactivity is typical of amide compounds, making it suitable for various synthetic applications.

Ethyl 1H-pyrazolo[3,4-B]pyridine-5-carboxylate (CAS: 1256824-48-2) is synthesized through the condensation of ethyl isonicotinate with 1H-pyrazolo[3,4-B]pyridine using a coupling agent like 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxybenzotriazole (HOBt). This process yields a high purity product with good selectivity and a yield of approximately 85%.

Ethyl 1H-pyrazolo[3,4-B]pyridine-5-carboxylate (CAS: 1256824-48-2) is primarily used in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of various medicinal compounds and can be used in the development of new drugs. Additionally, it has potential applications in the synthesis of polymers and materials for sensors and semiconductors.

When handling Ethyl 1H-pyrazolo[3,4-B]pyridine-5-carboxylate (CAS: 1256824-48-2), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be used in a well-ventilated area or a fume hood to prevent inhalation. Spills should be handled carefully using absorbent materials and the area should be flushed with water. For detailed safety information, refer to the Safety Data Sheet (SDS).