6-Hydroxy-4(1H)-quinazolinone(CAS: 16064-10-1)

6-Hydroxy-4(1H)-quinazolinone is a crystalline solid with a molecular weight of approximately 206.16 g/mol. It is slightly soluble in water but soluble in most organic solvents. Chemically, it is known for its stability and limited reactivity under normal conditions, making it suitable for various applications.

6-Hydroxy-4(1H)-quinazolinone can be synthesized through the condensation of 4-aminobenzaldehyde and 2-hydroxybenzaldehyde in the presence of a base. The reaction is typically carried out at room temperature with a yield of around 75-80%. The use of a suitable catalyst can improve the selectivity and yield of the product.

6-Hydroxy-4(1H)-quinazolinone is widely used in pharmaceuticals for its potential as an antiviral agent, in polymer production for its stabilizing and reinforcing properties, and in sensors for its ability to detect specific chemicals. It also finds applications in semiconductors for doping purposes.

When handling 6-Hydroxy-4(1H)-quinazolinone, it is recommended to use personal protective equipment such as gloves and safety goggles. The substance should be stored in a cool, dry place away from direct sunlight and flammable materials. In case of spill, it should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.