Chloroacetamido-PEG4-NHS Ester(CAS: 1353011-95-6)

Chloroacetamido-PEG4-NHS Ester (CAS: 1353011-95-6) is a white or off-white solid in its crystalline form. Its molecular weight is approximately 364.5 g/mol. It has a relatively low water solubility and high reactivity towards amine-containing compounds, making it suitable for conjugation reactions. It is soluble in polar organic solvents like DMSO and DMF.

Chloroacetamido-PEG4-NHS Ester (CAS: 1353011-95-6) is synthesized by reacting PEG4-NHS Ester with chloroacetyl chloride in the presence of a suitable solvent and a base. The reaction yields a high purity product with good selectivity and a high yield. The key steps involve the formation of an amide bond via an acyl chlorination reaction.

Chloroacetamido-PEG4-NHS Ester (CAS: 1353011-95-6) is widely used in pharmaceuticals for drug conjugation, in polymers for creating functionalized materials, and in sensors for labeling biomolecules. It also finds applications in semiconductors for surface functionalization and in biomedical research for attaching molecules to surfaces.

When handling Chloroacetamido-PEG4-NHS Ester (CAS: 1353011-95-6), it is crucial to use proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up with caution using appropriate spill kits. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.