1,3-Thiazole-2-sulfonyl chloride(CAS: 100481-09-2)

1,3-Thiazole-2-sulfonyl chloride (CAS: 100481-09-2) is a white crystalline solid with a molecular weight of 225.19 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. Chemically, it is reactive, particularly towards nucleophiles, and can undergo substitution reactions.

1,3-Thiazole-2-sulfonyl chloride is commonly synthesized by the reaction of 1,3-thiazole-2-sulfonic acid with thionyl chloride. This process yields the compound in good yield with high selectivity, often involving the use of a minimal amount of catalyst or reagent.

1,3-Thiazole-2-sulfonyl chloride (CAS: 100481-09-2) is utilized in pharmaceuticals for drug synthesis, in polymers for functionalization, and in sensor technology for detecting various analytes. It also finds applications in semiconductor manufacturing for surface modification.

When handling 1,3-Thiazole-2-sulfonyl chloride (CAS: 100481-09-2), wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work in a fume hood to minimize exposure. Store in a cool, dry place away from incompatible materials. Refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.