N,N-Bis(2-hydroxyethyl)-4-methylbenzenesulfonamide(CAS: 7146-67-0)

N,N-Bis(2-hydroxyethyl)-4-methylbenzenesulfonamide (CAS: 7146-67-0) is a white crystalline solid with a molecular weight of approximately 269.27 g/mol. It is slightly soluble in water and has a pKa of about 7.4. The compound is moderately reactive towards nucleophiles and is used in various synthetic applications due to its amide functionality. It also shows activity as a potential histone deacetylase inhibitor in biochemistry.

N,N-Bis(2-hydroxyethyl)-4-methylbenzenesulfonamide can be synthesized by reacting 4-methylbenzenesulfonic acid with ethylene glycol in the presence of a strong base such as potassium hydroxide. The reaction proceeds via a nucleophilic substitution mechanism, yielding the desired amide product with good selectivity and yield. Conditions are typically carried out at elevated temperatures and under inert atmosphere to prevent side reactions.

N,N-Bis(2-hydroxyethyl)-4-methylbenzenesulfonamide (CAS: 7146-67-0) finds application in pharmaceuticals as a potential intermediate in the synthesis of drugs, particularly those targeting histone deacetylase activity. It is also used in the production of certain polymers and as a reagent in analytical chemistry for sensor development. Additionally, it has applications in semiconductor manufacturing.

When handling N,N-Bis(2-hydroxyethyl)-4-methylbenzenesulfonamide (CAS: 7146-67-0), it is essential to wear appropriate personal protective equipment (PPE), including gloves, laboratory coat, and safety glasses. The compound should be handled in a well-ventilated area or fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents, and the area should be well-ventilated. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.