2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine(CAS: 445264-61-9)

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a crystalline solid with a molecular weight of approximately 344.4 g/mol. It is soluble in organic solvents like THF and DMSO but has limited solubility in water. The compound shows moderate reactivity towards nucleophiles, making it useful in various synthetic transformations. It is stable under normal laboratory conditions but should be stored away from moisture and heat.

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is typically synthesized via a cross-coupling reaction. The synthesis involves the reaction of 5-bromopyridine with a boronic acid ester in the presence of a phase transfer catalyst like tetrabutylammonium fluoride (TBAF) and a base like triethylamine. The yield is generally high, and the reaction is known for its high regioselectivity and tolerance of functional groups.

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine finds applications in the pharmaceutical industry, particularly in the synthesis of complex organic molecules. It is also used in the polymer industry for the modification of polymers and in semiconductor industry for the production of electronic materials. Additionally, it is utilized in sensor technology for the detection of various analytes.

When handling 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation of the vapors. Spills should be cleaned up immediately using appropriate absorbents, and the area should be well-ventilated before continuing work. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.