1-(Phenoxycarbonyl)pyrrolidine-2-carboxylic acid(CAS: 1161602-22-7)

1-(Phenoxycarbonyl)pyrrolidine-2-carboxylic acid is a white crystalline solid at room temperature. Its molecular weight is approximately 289.23 g/mol. It is slightly soluble in water and moderately soluble in ethanol. The compound exhibits basic properties and can form salts with acids. It is stable under normal conditions but can undergo hydrolysis under acidic or basic conditions.

1-(Phenoxycarbonyl)pyrrolidine-2-carboxylic acid is synthesized through the condensation of phenol and 2-cyano-1-pyrrolidinecarboxylic acid. The reaction is catalyzed by a weak base and typically yields a mixture of products. The process requires careful control of temperature and reaction time to achieve the desired product. The yield is moderate, and the product can be purified by recrystallization.

1-(Phenoxycarbonyl)pyrrolidine-2-carboxylic acid is primarily used in the pharmaceutical industry as a precursor for the synthesis of various biologically active compounds. It is also used in the polymer industry for the preparation of functionalized polymers and in the sensor industry for developing chemical sensors due to its reactivity and structural properties.

When handling 1-(Phenoxycarbonyl)pyrrolidine-2-carboxylic acid, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from heat sources. It should be handled in a well-ventilated area or fume hood to minimize inhalation risk. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials. For detailed safety information, refer to the Material Safety Data Sheet (MSDS/SDS).