(S)-1-Cyclohexyl-2,2,2-trifluoro-ethylamine(CAS: 75703-08-1)

(S)-1-Cyclohexyl-2,2,2-trifluoro-ethylamine is a colorless to white crystalline solid with a molecular weight of approximately 209.21 g/mol. It has a low water solubility and is soluble in organic solvents like ethanol and acetone. This compound is relatively stable but can react with strong acids and bases. It forms a crystalline solid with a melting point around 65-67°C.

(S)-1-Cyclohexyl-2,2,2-trifluoro-ethylamine can be synthesized through a multi-step process involving the reaction of trifluoromethyl chloride with cyclohexylamine. The process typically involves Noyori asymmetric hydrogenation to achieve enantioselectivity. Common catalysts include chiral ligands and palladium complexes. The yield and selectivity can be optimized through careful control of reaction conditions.

(S)-1-Cyclohexyl-2,2,2-trifluoro-ethylamine is primarily used in the pharmaceutical industry for the synthesis of various drug candidates, particularly those requiring trifluoromethyl functionalities. It is also used in the polymer industry to enhance the properties of certain materials. Additionally, it finds applications in the sensor and semiconductor industries for specific modification and functionalization purposes.

When handling (S)-1-Cyclohexyl-2,2,2-trifluoro-ethylamine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up carefully using appropriate absorbents, and the area should be well-ventilated. Always refer to the Material Safety Data Sheet (MSDS) for specific safety guidelines and emergency procedures.