How is (S)-1-Cyclohexyl-2,2,2-trifluoro-ethylamine (CAS: 75703-08-1) typically synthesized?

(S)-1-Cyclohexyl-2,2,2-trifluoro-ethylamine can be synthesized through a multi-step process involving the reaction of trifluoromethyl chloride with cyclohexylamine. The process typically involves Noyori asymmetric hydrogenation to achieve enantioselectivity. Common catalysts include chiral ligands and palladium complexes. The yield and selectivity can be optimized through careful control of reaction conditions.