3-Fluoro-2-(trifluoromethyl)benzoic acid(CAS: 261951-80-8)

3-Fluoro-2-(trifluoromethyl)benzoic acid (CAS: 261951-80-8) is a white crystalline solid with a molecular weight of 227.06 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. The compound is known for its high reactivity in nucleophilic substitution and electrophilic aromatic substitution reactions.

3-Fluoro-2-(trifluoromethyl)benzoic acid is typically synthesized via the Friedel-Crafts alkylation of 2-(trifluoromethyl)benzoic acid with fluorobenzene in the presence of aluminum chloride as a catalyst. The reaction yields a mixture, but selective methods can be used to improve product purity.

3-Fluoro-2-(trifluoromethyl)benzoic acid (CAS: 261951-80-8) is used in the pharmaceutical industry for the synthesis of certain drugs due to its unique chemical properties. It is also used in polymer and sensor applications, as well as in the electrochemical industry for its conductivity and reactivity.

When handling 3-Fluoro-2-(trifluoromethyl)benzoic acid (CAS: 261951-80-8), wear appropriate personal protective equipment (PPE) including gloves and safety glasses. Store the compound in a fume hood or well-ventilated area to avoid inhalation of fumes. Follow standard laboratory safety procedures, and refer to the Material Safety Data Sheet (MSDS) for detailed handling instructions. Dispose of any waste in accordance with local regulations.