2-Chloro-3-methylbenzonitrile(CAS: 15013-71-5)

2-Chloro-3-methylbenzonitrile (CAS: 15013-71-5) is a colorless to light yellow liquid with a molecular weight of approximately 168.04 g/mol. It has a low solubility in water but is readily soluble in organic solvents like ethanol and acetone. It is moderately reactive, especially towards nucleophiles, and can undergo substitution and addition reactions. It crystallizes in the monoclinic system at low temperatures.

2-Chloro-3-methylbenzonitrile is typically synthesized via the reaction of chloromethylbenzene with sodium cyanide in an aprotic solvent like dimethylformamide (DMF) under basic conditions. The reaction is exothermic and requires careful temperature control to achieve high yields and selectivity. The process is catalyzed by a base such as potassium carbonate.

2-Chloro-3-methylbenzonitrile (CAS: 15013-71-5) is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those involving nitrile functionalities. It also finds applications in the polymer industry as a monomer for the production of various plastic materials. Additionally, it is used in the production of electronic materials and in environmental applications due to its reactivity.

Handling 2-Chloro-3-methylbenzonitrile (CAS: 15013-71-5) requires appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to prevent inhalation. Spills should be cleaned up carefully, and all materials should be disposed of according to local regulations. The safety data sheet (SDS) should be consulted for specific handling and storage guidelines.