3-Bromo-2-thiophenecarboxylic acid(CAS: 7311-64-0)

3-Bromo-2-thiophenecarboxylic acid is a white crystalline solid with a molecular weight of approximately 214.03 g/mol. It has a melting point of 135-136°C and is slightly soluble in water. It is reactive towards nucleophiles and can undergo substitution reactions. The compound is stable under normal conditions but should be stored in a dry, cool place away from direct sunlight.

3-Bromo-2-thiophenecarboxylic acid is typically synthesized by bromination of 2-thiophenecarboxylic acid. The bromination is usually carried out using bromine in the presence of a Lewis acid catalyst, such as aluminum bromide, in an appropriate solvent like dichloromethane. The reaction is exothermic and should be performed under nitrogen atmosphere to avoid side reactions.

3-Bromo-2-thiophenecarboxylic acid is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals, particularly in the preparation of drugs targeting specific receptors. It is also used in the production of sensors, semiconductors, and polymers due to its unique chemical properties.

When handling 3-Bromo-2-thiophenecarboxylic acid, it is essential to use proper personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a fume hood to minimize exposure. In case of a spill, it should be carefully cleaned up using appropriate absorbents, and the area should be well ventilated. Always consult the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.