Onalespib(CAS: 912999-49-6)

Onalespib is a small molecule with a molecular weight of approximately 309.15 g/mol. It is poorly water-soluble and exhibits poor solubility in common organic solvents. Onalespib is a crystalline solid under normal conditions. Its stability is influenced by acidic and basic conditions, and it is reactive towards nucleophiles. It is not typically flammable but requires careful handling due to its reactivity.

Onalespib is synthesized through a multi-step process involving coupling reactions, alkylation, and reduction steps. The synthesis requires the use of various catalysts and reagents such as triphenylphosphine and sodium hydride. The overall yield is moderate, and the reaction conditions must be strictly controlled to achieve high selectivity and purity.

Onalespib is primarily used in the pharmaceutical industry for research purposes, particularly in the development of targeted cancer therapies. It is also of interest in academic and research institutions for exploring its potential in various biological assays and drug discovery programs.

When handling Onalespib, proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat must be worn. It is recommended to use a fume hood during any manipulations to minimize exposure. Spills should be handled with appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.