Ethyl 5-(aminomethyl)-1,3,4-oxadiazole-2-carboxylate hydrochloride(CAS: 652158-84-4)

Ethyl 5-(aminomethyl)-1,3,4-oxadiazole-2-carboxylate hydrochloride is a crystalline solid with a molecular weight of approximately 289.7 g/mol. It is slightly soluble in water and more soluble in organic solvents. The compound is known for its low reactivity in most conditions but can react with strong bases. It has a pKa of 1.2 and forms a stable salt in aqueous solutions.

Ethyl 5-(aminomethyl)-1,3,4-oxadiazole-2-carboxylate hydrochloride is typically synthesized through the reaction of ethyl 5-(chloromethyl)-1,3,4-oxadiazole-2-carboxylate with sodium amide in an aprotic solvent like dimethylformamide (DMF). The yield is around 85-90%, and the reaction is carried out under an inert atmosphere to prevent oxidation.

Ethyl 5-(aminomethyl)-1,3,4-oxadiazole-2-carboxylate hydrochloride is used in the pharmaceutical industry for the synthesis of certain medicinal compounds. It is also utilized in the polymer industry for modifying polymer properties and in the sensor industry for developing chemical sensors due to its reactive functional groups.

When handling Ethyl 5-(aminomethyl)-1,3,4-oxadiazole-2-carboxylate hydrochloride, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and laboratory coats. The compound should be stored in a cool, dry place away from sources of heat and moisture. Spills should be handled with suitable absorbent materials and disposed of according to local hazardous waste regulations. Always refer to the Safety Data Sheet (SDS) for detailed information on storage and handling.