1-Methoxy-2-propanyl propionate(CAS: 148462-57-1)

1-Methoxy-2-propanyl propionate is a colorless to slightly yellowish liquid with a molecular weight of approximately 132.18 g/mol. It has a moderate solubility in water and is miscible with common organic solvents. This compound is known to be moderately reactive, particularly in the presence of bases or under acidic conditions. It has a pKa of around 14, indicating basic behavior. It is crystalline at low temperatures and exhibits good thermal stability up to 100°C.

1-Methoxy-2-propanyl propionate is typically synthesized through a Grignard reaction followed by esterification. Specifically, 2-propanol is reacted with a Grignard reagent derived from methoxy magnesium chloride, and the product is then treated with acetic anhydride to form the ester. This method provides good yield and selectivity, although the use of Grignard reagents requires strict handling procedures to prevent hazardous side reactions.

1-Methoxy-2-propan-2-yl propionate is used in the pharmaceuticals industry as an intermediate in the synthesis of certain drugs. It is also utilized in the polymer industry as a monomer and in the development of functional polymers. Additionally, it has applications in the production of sensors and semiconductors, where its chemical properties make it suitable for specific functional groups and reactions.

When handling 1-Methoxy-2-propan-2-yl propionate, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and lab coat. The compound should be used in a well-ventilated area or under a fume hood due to its reactivity. Spills should be cleaned up carefully, and the material safety data sheet (MSDS) should be consulted for specific cleanup procedures. It is also crucial to store the compound in a cool, dry place, away from strong acids, bases, and oxidizers to prevent degradation and hazardous reactions.