Icatibant(CAS: 130308-48-4)

Icatibant is a white crystalline powder with a molecular weight of approximately 365.4 g/mol. It is sparingly soluble in water and ethanol. Chemically, it is a potent and selective bradykinin B2 receptor antagonist. Its reactivity is low under normal conditions, but it can hydrolyze under basic conditions.

Icatibant is typically synthesized through multi-step reactions involving coupling of a protected amino acid with a protected compound, followed by deprotection and final purification. Commonly used catalysts include tetrabutylammonium fluoride (TBAF) and other fluoride-based reagents. The overall yield is around 50-60%.

Icatibant finds its primary application in the pharmaceutical industry, particularly for the treatment of hereditary angioedema. It is also explored in research for potential use in the diagnosis and treatment of other inflammatory conditions. However, its specific use in other industries like polymers, sensors, or semiconductors is limited.

Handling icatibant requires appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be immediately cleaned up with appropriate materials, and the Material Safety Data Sheet (MSDS) should be consulted for detailed instructions. Storage should be in a cool, dry place away from direct sunlight and heat sources.