Difluoro(phenyl)acetic acid(CAS: 360-03-2)

Difluoro(phenyl)acetic acid (CAS: 360-03-2) is a white crystalline solid with a molecular weight of approximately 184.05 g/mol. It has a low solubility in water (2.56 g/L at 20°C) but is more soluble in organic solvents like ethanol and dichloromethane. The compound is relatively stable under normal conditions but can react with strong bases to form the corresponding salts. It is a carboxylic acid and can undergo typical acid-base reactions.

Difluoro(phenyl)acetic acid (CAS: 360-03-2) is typically synthesized via the Friedel-Crafts acylation of a phenyl derivative with acetyl chloride in the presence of aluminum chloride as a catalyst. The reaction involves the introduction of the acetyl group onto the phenyl ring followed by the subsequent conversion to the carboxylic acid function. This process provides good yield and high selectivity.

Difluoro(phenyl)acetic acid (CAS: 360-03-2) is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals and agrochemicals due to its reactivity. Additionally, it is utilized in the polymer industry for the development of special polymers and in the semiconductor industry for the production of photoresists and other electronic materials. Its use in sensors and as a ligand in coordination chemistry is also reported.

When handling Difluoro(phenyl)acetic acid (CAS: 360-03-2), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be used in a fume hood to minimize exposure to fumes. Spills should be carefully cleaned up using appropriate absorbents, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for specific handling and disposal instructions. Storage should be in a cool, dry place away from incompatible materials.