2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenol(CAS: 627906-52-9)

2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenol is a solid at room temperature with a molecular weight of approximately 328.44 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. It exhibits low reactivity under normal conditions but can undergo boron-containing reactions. Its melting point is around 110-112°C.

This compound is commonly synthesized using a Grignard reaction followed by borate ester formation. The Grignard reagent is generated from 2-methylphenol and magnesium, which is then reacted with 1,3,2-dioxaborinane in the presence of a base like potassium tert-butoxide to form the desired product. The reaction is typically carried out in anhydrous conditions to prevent side reactions.

2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenol is utilized in the pharmaceutical industry for its role in organic synthesis, particularly in the development of boron-containing drugs. It is also used in the polymer industry for modifying polymer properties and in analytical chemistry for sensor development.

When handling 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenol, it is important to wear appropriate personal protective equipment (PPE) including gloves and safety glasses. It should be handled in a well-ventilated area or fume hood. Spills should be cleaned up with appropriate absorbent materials and proper disposal procedures should be followed. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.