4-Amino-1H-isoindole-1,3(2H)-dione(CAS: 2518-24-3)

4-Amino-1H-isoindole-1,3(2H)-dione is a yellow crystalline solid with a molecular weight of 187.18 g/mol. It has a melting point of 220-222°C and is slightly soluble in water. It is chemically reactive and can undergo substitution reactions and condensation reactions.

4-Amino-1H-isoindole-1,3(2H)-dione can be synthesized via the cyclization of 2-aminobenzaldehyde oxime with acetic anhydride. This reaction is catalyzed by p-toluenesulfonic acid and typically yields 70-80% of the product. The process requires careful control of temperature and reaction time to achieve high selectivity.

4-Amino-1H-isoindole-1,3(2H)-dione is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those targeting cardiovascular and neurological systems. It is also used in the production of some polymer and sensor materials due to its structural properties.

4-Amino-1H-isoindole-1,3(2H)-dione should be handled in a well-ventilated area with the use of personal protective equipment (PPE), including gloves, goggles, and a lab coat. It is important to use a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials and the area should be rinsed with water. Consult the Safety Data Sheet (SDS) for detailed instructions.