2-Bromo-3-fluorobenzoic acid(CAS: 132715-69-6)

2-Bromo-3-fluorobenzoic acid is a crystalline solid with a molecular weight of approximately 220.03 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. This compound exhibits moderate reactivity towards nucleophiles and is less reactive towards electrophiles. It has a melting point of around 184-186°C.

2-Bromo-3-fluorobenzoic acid is typically synthesized through the bromination of 3-fluorobenzoic acid using a brominating agent like N-bromosuccinimide (NBS) in the presence of a radical initiator such as AIBN. The reaction is performed in an inert atmosphere to prevent decomposition and yields a product with good selectivity and up to 90% yield.

2-Bromo-3-fluorobenzoic acid is used in the pharmaceutical industry for the synthesis of certain drugs and intermediates. It is also utilized in the polymer industry as a monomer for polymeric materials. Additionally, it has applications in the sensor and semiconductor industries for specific chemical and physical sensing applications.

When handling 2-Bromo-3-fluorobenzoic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up with appropriate protective measures, and the material safety data sheet (MSDS) should be consulted for detailed spill cleanup procedures. Storage should be in a cool, dry place, away from incompatible materials.