4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl acetate(CAS: 740081-22-5)

4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl acetate is a white crystalline solid. Its molecular weight is approximately 453.18 g/mol. It has low solubility in water but good solubility in organic solvents such as methanol and acetonitrile. The compound exhibits moderate reactivity towards nucleophiles and is stable under normal storage conditions. It does not readily decompose under acidic or basic conditions.

4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl acetate can be synthesized via a multi-step process involving the condensation of 3-(chloro-2-fluorophenyl)hydrazine with 7-methoxy-6-quinazoline, followed by acetylation. Commonly used acids include acetic anhydride, and the reaction is typically carried out in the presence of a catalyst such as pyridine. The product exhibits high selectivity and yield under optimized conditions.

4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl acetate is primarily used in the pharmaceutical industry for the development of novel drugs. It also has potential applications in the polymer industry for the synthesis of advanced materials and in the semiconductor industry for the fabrication of electronic devices and sensors. Its specific functionalities make it a valuable compound in these fields.

When handling 4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl acetate, it is essential to wear appropriate personal protective equipment such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a chemical fume hood to avoid inhalation of dust or vapors. Spills should be cleaned up immediately using appropriate absorbents, and waste should be disposed of in accordance with local regulations. Always consult the safety data sheet (SDS) for detailed handling instructions and emergency procedures.