2,4-Dichloro-7-(trifluoromethyl)quinazoline(CAS: 396-02-1)

2,4-Dichloro-7-(trifluoromethyl)quinazoline (CAS: 396-02-1) is a solid crystalline compound with a molecular weight of approximately 355.02 g/mol. It has low water solubility and high solubility in organic solvents like dichloromethane and acetonitrile. This compound is chemically stable but can react with reducing agents. It is insoluble in water and soluble in common organic solvents.

2,4-Dichloro-7-(trifluoromethyl)quinazoline (CAS: 396-02-1) is typically synthesized through a multistep process involving chlorination and trifluoromethylation reactions. The synthesis involves the use of chlorinating agents like thionyl chloride and trifluoromethylating reagents like trifluoromethyl chloroformate. The yield is moderate to high, and the reaction conditions include careful temperature control.

2,4-Dichloro-7-(trifluoromethyl)quinazoline (CAS: 396-02-1) is primarily used in pharmaceuticals for the development of potential anticancer and antiviral drugs. It is also utilized in the synthesis of various organic compounds and materials, including polymers and functional molecules for sensors and semiconductors.

When handling 2,4-Dichloro-7-(trifluoromethyl)quinazoline (CAS: 396-02-1), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood or a well-ventilated area. Spills should be cleaned up using appropriate absorbent materials and proper disposal procedures. Always refer to the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.